Bioinorganic Chemistry Research Group

The accumulation of toxic heavy metals represents one of the major risk for the future of human society. In the last few centuries the industrialization and worldwide civilization significantly enhanced the use of these elements and this was accompanied by a dramatic increase of their concentration in the living systems. The beneficial properties of heavy metals will be important in the future, too. In parallel, appropriate steps are required to avoid further contaminations and reduce their harmful effects. New and selective chelating agents will be designed in the frame of the project. The range of metal ions includes the well-known toxic metals like lead and cadmium and also nickel and platinum metals which are increasingly used in modern equipments and represent a new challenge for the environment. These elements are generally bonded to proteins and their fragments under natural conditions and this principle will be followed during the development of new complexing agents. The studies performed in the frame of the project include the design and synthesis of new derivatives of amino acids, peptides and hydroxamic acids and systematic comparison of their metal binding affinities.

 

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